For instance, animal studies and clinical experiments indicate that resins placed in deep cavities with little remain dentin thickness or in direct contact with the dental pulp may cause a chronic persistent inflammation. Even less information is available if resin substances may cause alterations in systemic cells. Another area, which is relatively ‘under-investigated’ are chemical interactions of resin compounds at low concentrations with cells and tissues.

An increasing number of studies, however, points out that resins at non-toxic or only moderately toxic concentration may significantly interfere with cells’ metabolism. Initiating systems, for example, significantly increased the amounts of intracellular reactive oxygen species. Monomers, like BisGMA, UDMA, TEGDMA, and HEMA can deplete the intracellular pool of detoxifying glutathione thus making the affected cells more susceptible to subsequent toxic challenges from other xenobiotics.

Finally, potential synergistic interactions between biologically active resin molecules and substances from other dental therapeutics, such as bleaching agents, may increase potential health risks. Taken together, the available results indicate that resin-modified materials could contribute to dysfunction and chronic diseases.


Objectives:
• Become familiar with leaching resin components
• Learn about potential local and systemic adverse reactions
• Get information about resin-associated cellular reactions and their possible health effects